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RESEARCH FINDINGS ON FREE RADICALS

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RESEARCH FINDINGS ON FREE RADICALS

Post by pmmutiti on Sat Sep 28, 2013 5:41 pm



Age is not just a number to Dr. Denham Harman. It's an obsession.


Why else would an 87-year-old man rise at 4:30 each morning, drive to the University of Nebraska Medical Center by 7 and put in an eight-hour day?


"Because I'm busy," Harman said. "If you don't stay busy, you die. I don't want to die right now." [url=http://www.blogger.com/Age is not just a number to Dr. Denham Harman. It%27s an obsession. Why else would an 87-year-old man rise at 4:30 each morning, drive to the University of Nebraska Medical Center by 7 and put in an eight-hour day? "Because I%27m busy," Harman said. "If you don%27t stay busy, you die. I don%27t want to die right now." http://www.cbsnews.com/stories/2003/06/13/health/main558663.shtml]http://www.cbsnews.com/stories/2003/06/13/health/main558663.shtml[/url]


Dr. Denham Harmon, M.D., Ph.D., first proposed a theory of aging as the indiscriminate chemical re-activity of free radicals possibly leading to random biological damage.

Harman’s Free Radical Theory of Aging has been considered as a major theory of aging for more than 50 years. In 1956 Dr. Harman proposed that the accumulation of free radicals with the age causes the damage of biomolecules by these reactive species and the development of pathological disorders resulting in cell senescence and organismal aging. His hypothesis was supported by numerous experimental studies demonstrated an increase in free radical levels in cells and living organisms with aging http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295029/





Free Radical and Oxidative Damage in Human Blood Cells.

Free radicals and oxidative damage play important roles in aging and many degenerative disorders such as cancer, cardiovascular diseases, and Alzheimer disease. Antioxidants can alleviate some of the harmful effects of oxidative damage. In this report, we describe that we have been using human red blood cells (RBCs) as a model system to delineate the effects of oxidative damage on human cells, particularly on glucose-6-phosphate dehydrogenase (G6PD)-deficient human RBCs.
http://www.ncbi.nlm.nih.gov/pubmed/12386388

Your body constantly reacts with oxygen as you breathe and your cells produce energy. As a consequence of this activity, highly reactive molecules are produced within our cells known as free radicals and oxidative stress occurs. When our protein-controlled (anti)-oxidant-response doesn’t keep up oxidative stress causes oxidative damage that has been implicated in the cause of many diseases (see list below on the left) and also has an impact on the body’s aging process. http://www.oxidativestressresource.org/


Free radicals, antioxidants and functional foods: Impact on human health

In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/

Some internally generated sources of free radicals are:


  • Mitochondria
  • Xanthine oxidase
  • Peroxisomes
  • Inflammation
  • Phagocytosis
  • Arachidonate pathways
  • Exercise
  • Ischemia/reperfusion injury
Some externally generated sources of free radicals are:

  • Cigarette smoke
  • Environmental pollutants
  • Radiation
  • Certain drugs, pesticides
  • Industrial solvents
  • Ozone
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/


Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis


There is ample evidence supporting a causative role of lipid peroxidation in selected human cancers, including kidney, liver and skin, and in degenerative diseases.
In experimental models, estrogen treatment induces lipid peroxidation and subsequently increases the incidence of renal cell cancer [32,33]. Because estrogen is a risk factor for breast cancer, it has been hypothesized, based on this model, that lipid peroxidation may be one mechanism by which estrogen increases breast cancer risk [11].
But estrogen induces renal cancer or liver cancer in this experimental model, not breast cancer. Indeed, lipid peroxidation may be a relevant mechanism for renal carcinogenesis, a concept that we have proposed and that is strongly supported by experimental and epidemiological data [32-34]
http://breast-cancer-research.com/content/9/1/201


In multicellular organisms, cells that are no longer needed or are a threat to the organism are destroyed by a tightly regulated cell suicide process known as programmed cell death, or apoptosis.
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Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain). Cejas P, Casado E, Belda-Iniesta C, De Castro J, Espinosa E, ...
http://adf.ly/TuHbC


Lipid peroxidation refers to the oxidative degradation of lipids. It is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. This process proceeds by a free radical chain reaction mechanism. It most often affects polyunsaturated fatty acids, because they contain multiple double bonds in between which lie methylene bridges (-CH2-) that possess especially reactive hydrogens. As with any radical reaction, the reaction consists of three major steps: initiation, propagation, and termination. http://adf.ly/TuIyx
Watch how human brain works: http://adf.ly/TuJgk


Our brain operates much like a computer, only is capable of more than any computer could do, and holds more information than a thousand computers. It can recall information faster than any processor, and does nott need a schedule to know to defrag or compact files.
Your brain is on duty 24/7, taking in everything you see, hear, smell, touch and taste. If some connections (neurons) are not working as they should new ones are formed to reroute the communication to another connection. Millions of neurons are working throughout our bodies at all hours of the day and night, telling us to breathe, sleep, blood to flow and even that we are not feeling well. http://adf.ly/TuKpF


Are you in awe of how people are able to recall so much of scripture, or can refer to specific passages for the appropriate occasion? This is no easy feat.
Take my word for it, there is no real trick when it comes to learning to memorize the Bible and all the verses, but there are a couple tips that I would be more than happy to share with you. http://adf.ly/TuLUV


Wholegrain foods, such as whole grain breads and wheat germ are some of the best brain foods. Whole grain breads, cereals, barley, popcorn boost blood flow to the brain, and the Vitamins B6, B12 and folic acid that they contain are essential in protecting your memory.

With the good there is sometimes the bad. Food allergies or the use of these highly nutritious brain friendly foods couple with toxins like nicotine, alcohol, and foods that contain trans fats and partially hydrogenated oils result in brain drain. http://adf.ly/TuMnV













Peter Mwaura M
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pmmutiti
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Peter Mwaura Mutiti : Teaching old blood cells new tricks:
When you hear someone mention circulation you probably think of the heart and major arteries—and for good reason. Circulatory disorders such as hypertension (high blood pressure) and atherosclerosis (hardening of the arteries) are major risk factors for heart disease, heart attacks, and stroke.

But there’s more to it than that. With all the attention on the heart and arteries, it’s easy to overlook serious health problems affecting the smallest components of the circulatory system—microscopic blood vessels called microcapillaries, where the critical exchange of oxygen and nutrients actually takes place. If blood isn’t flowing through this web properly, it can trigger all sorts of health problems, many of which may not seem related to circulation at all.

A number of factors contribute to poor circulation as we age. Arteries and veins become stiff and congested as cholesterol and calcium plaques accumulate and restrict blood flow. Spasms in the smooth muscles surrounding the circulatory arteries and veins can also choke off circulation. These same processes also occur in our microcapillaries, reducing microcirculation and impairing the critical exchange of nutrients and gases in tissues and major organs.

This problem only gets worse as we get older because of changes in the composition and structure of blood cells. As you reach middle age, the blood starts to thicken and congeal as platelets and blood proteins make cells sticky. Plus, the spleen—the organ that removes old, damaged blood cells from circulation—begins to slow down with age, which means new, healthy blood cells are replaced at a sharply reduced rate. And to make matters even worse, as blood cells age, they become stiff and no longer appear round and evenly shaped. This makes it harder for them to pass smoothly through the capillaries. In fact, the angular, jagged shape of the old cells can damage the fragile microcapillaries even further.

Eventually, these age-related changes take their toll on the microcapillaries, reducing circulation to the tissues and blocking the flow of nutrients and oxygen. Removal of carbon dioxide and other metabolic waste products is also hindered. This leads to a slow buildup of metabolic garbage that can gradually bury the cells in their own waste products. In time, the cells, poisoned by their own metabolic byproducts, begin to waste away and ultimately cease to function altogether.

The combined effect of poor circulation and old blood contributes to a host of symptoms, including deep fatigue, fuzzy thinking, frequent infections, and lowered sex drive—all conditions usually considered just “normal parts of aging.”

If circulation doesn’t improve, it can lead to more serious conditions, such as high blood pressure, heart attack, stroke, diabetes, and arthritis. But giving your body a fresh supply of healthy blood may target all of these problems and more.
Ann Njoki : Forum assistant
Registration date : 2008-01-10

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