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ULCERATIVE COLITIS

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ULCERATIVE COLITIS

Post by pmmutiti on Tue Jun 24, 2008 5:21 pm

Ulcerative colitis, a common form of inflammatory bowel disease, is accompanied by an increased level of leukotriene B4 in the lining of the colon. Fish oils are known to inhibit the synthesis of leukotrienes and it has therefore been postulated that they might be beneficial in the treatment of ulcerative colitis. Researchers at the Veterans Affairs Medical Center have just released the results of a study aimed at testing this hypothesis.

The study involved 11 male patients aged 31 to 74 years who had been diagnosed with ulcerative colitis. The patients were randomized into two groups with one group receiving 15 fish oil capsules (providing 2.7 grams of eicosapentaenoic acid (EPA) and 1.8 grams of docosahexaenoic acid (DHA) daily); the other group received placebo capsules (olive oil). After 3 months on the supplements all participants underwent a 2-month wash-out period and were then assigned to the opposite treatment to what they had received during the first stage for another 3 months. Clinical evaluations of all patients were performed at the start of the study and every month thereafter.

Evaluation of the patients' clinical data at the end of the treatment periods showed a significant beneficial effect of fish oil supplementation. The mean disease severity score for the patients on fish oil declined by 56% as compared to 4% for the placebo group. Eight of the 11 patients (72%) were able to markedly reduce or totally eliminate their use of anti-inflammatory medication and steroids while taking the fish oils.

The researchers conclude that fish oil supplementation results in a marked clinical improvement of active mild to moderate ulcerative colitis.


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Peter Mwaura Mutiti : Teaching old blood cells new tricks:
When you hear someone mention circulation you probably think of the heart and major arteries—and for good reason. Circulatory disorders such as hypertension (high blood pressure) and atherosclerosis (hardening of the arteries) are major risk factors for heart disease, heart attacks, and stroke.

But there’s more to it than that. With all the attention on the heart and arteries, it’s easy to overlook serious health problems affecting the smallest components of the circulatory system—microscopic blood vessels called microcapillaries, where the critical exchange of oxygen and nutrients actually takes place. If blood isn’t flowing through this web properly, it can trigger all sorts of health problems, many of which may not seem related to circulation at all.

A number of factors contribute to poor circulation as we age. Arteries and veins become stiff and congested as cholesterol and calcium plaques accumulate and restrict blood flow. Spasms in the smooth muscles surrounding the circulatory arteries and veins can also choke off circulation. These same processes also occur in our microcapillaries, reducing microcirculation and impairing the critical exchange of nutrients and gases in tissues and major organs.

This problem only gets worse as we get older because of changes in the composition and structure of blood cells. As you reach middle age, the blood starts to thicken and congeal as platelets and blood proteins make cells sticky. Plus, the spleen—the organ that removes old, damaged blood cells from circulation—begins to slow down with age, which means new, healthy blood cells are replaced at a sharply reduced rate. And to make matters even worse, as blood cells age, they become stiff and no longer appear round and evenly shaped. This makes it harder for them to pass smoothly through the capillaries. In fact, the angular, jagged shape of the old cells can damage the fragile microcapillaries even further.

Eventually, these age-related changes take their toll on the microcapillaries, reducing circulation to the tissues and blocking the flow of nutrients and oxygen. Removal of carbon dioxide and other metabolic waste products is also hindered. This leads to a slow buildup of metabolic garbage that can gradually bury the cells in their own waste products. In time, the cells, poisoned by their own metabolic byproducts, begin to waste away and ultimately cease to function altogether.

The combined effect of poor circulation and old blood contributes to a host of symptoms, including deep fatigue, fuzzy thinking, frequent infections, and lowered sex drive—all conditions usually considered just “normal parts of aging.”

If circulation doesn’t improve, it can lead to more serious conditions, such as high blood pressure, heart attack, stroke, diabetes, and arthritis. But giving your body a fresh supply of healthy blood may target all of these problems and more.
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